*Estimates of patients treated reflect global data since launch (Apr 2014-Mar 2023; US=58% of
data). Calculations based on observed drug utilization parameters and number of units distributed. Utilization patterns change over time to best represent current
FDA, U.S. Food and Drug Administration; PsA, psoriatic arthritis; TB, tuberculosis.
References: 1. Otezla [package insert]. Thousand Oaks, CA: Amgen Inc. 2. Data
on file, Amgen Inc. 3. Otezla® (apremilast) FDA approval letter. March 21, 2014.
ENCOURAGE COMMERCIALLY INSURED PATIENTS TO ENROLL IN
THE $0 CO-PAY CARD PROGRAM FOR OTEZLA BEFORE LEAVING THE OFFICE
WE ARE COMMITTED TO HELPING YOUR PATIENTS ACCESS OTEZLA AT LOW COST
If your patients are uninsured or underinsured, Amgen® Safety Net Foundation is a nonprofit patient assistance program sponsored by Amgen® that helps qualifying patients access Amgen medicines at no cost. Click here to learn more.
Amgen® SupportPlus Specialists help your Medicare patients understand their current insurance plan and anticipated out-of-pocket costs for Otezla. For patients that want to switch Medicare plans, we can help identify other local options. We may also be able to refer eligible patients for Medicare Extra Help (Low Income Subsidy) or put them in touch with independent nonprofit foundations. †
†Support provided through independent nonproﬁt foundations and not through Amgen® SupportPlus. Amgen® SupportPlus has no control over independent, third-party programs and provides referrals as a courtesy only.
AMGEN® NURSE PARTNERS
Dedicated Amgen® Nurse Partners will be with your patients along the way
to offer supplemental support and provide information about resources to
help them access their prescribed Amgen medication.
Amgen® Nurse Partners can provide supplemental support, including:
Guidance on resources that may help lower out-of-pocket medication costs
Assistance to help your patients stay on track with their medication
Answers to your questions about Amgen® SupportPlus
Your Otezla patients can enroll in the Amgen Nurse Partner Program online at
https://www.otezla.com/enroll or by calling 1-844-4OTEZLA (1-844-468-3952).
Amgen® Nurse Partners are only available to patients that are prescribed certain Amgen
products. They are not part of your treatment team and do not provide medical advice, nursing,
or case management services. Amgen® Nurse Partners will not inject patients with Amgen
medications. Patients should always consult their healthcare provider regarding medical
decisions or treatment concerns.
GET CONNECTED WITH A DEDICATED AMGEN® NURSE PARTNER BY CALLING
Otezla is contraindicated in
patients with a known
hypersensitivity to apremilast or to any of the excipients in the formulation
Warnings and Precautions
Hypersensitivity reactions, including angioedema and anaphylaxis, have been reported during postmarketing
surveillance. If signs or symptoms of serious hypersensitivity reactions occur, discontinue Otezla and
institute appropriate therapy
IMPORTANT SAFETY INFORMATION
Otezla is contraindicated in patients with a known hypersensitivity to apremilast or to any of the excipients in the formulation
Warnings and Precautions
Hypersensitivity: Hypersensitivity reactions, including angioedema and anaphylaxis, have been reported during postmarketing surveillance. If signs or symptoms of serious hypersensitivity reactions occur, discontinue Otezla and institute appropriate therapy
Diarrhea, Nausea, and Vomiting: Cases of severe diarrhea, nausea, and vomiting were associated with the use of Otezla. Most events occurred within the first few weeks of treatment. In some cases, patients were hospitalized. Patients 65 years of age or older and patients taking medications that can lead to volume depletion or hypotension may be at a higher risk of complications from severe diarrhea, nausea, or vomiting. Monitor patients who are more susceptible to complications of diarrhea or vomiting; advise patients to contact their healthcare provider. Consider Otezla dose reduction or suspension if patients develop severe diarrhea, nausea, or vomiting
Depression: Carefully weigh the risks and benefits of treatment with Otezla for patients with a history of depression and/or suicidal thoughts/behavior, or in patients who develop such symptoms while on Otezla. Patients, caregivers, and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes, and they should contact their healthcare provider if such changes occur
Plaque Psoriasis: Treatment with Otezla is associated with an increase in depression. During clinical trials in patients with moderate to severe plaque psoriasis, 1.3% (12/920) of patients
reported depression compared to 0.4% (2/506) on placebo. Depression was reported as serious in 0.1% (1/1308) of patients exposed to Otezla, compared to none in placebo-treated patients (0/506). Suicidal behavior was
observed in 0.1% (1/1308) of patients on Otezla, compared to 0.2% (1/506) on placebo. One patient treated with Otezla attempted suicide; one patient on placebo committed suicide
Psoriatic Arthritis: Treatment with Otezla is associated with an increase in depression. During clinical trials, 1.0% (10/998) reported depression or depressed mood compared to 0.8%
(4/495) treated with placebo. Suicidal ideation and behavior was observed in 0.2% (3/1441) of patients on Otezla, compared to none in placebo-treated patients. Depression was reported as serious in 0.2% (3/1441) of
patients exposed to Otezla, compared to none in placebo-treated patients (0/495). Two patients who received placebo committed suicide compared to none on Otezla
Behçet’s Disease: Treatment with Otezla is associated with an increase in depression. During the clinical trial, 1% (1/104) reported depression or depressed mood compared to 1% (1/103)
treated with placebo. No instances of suicidal ideation or behavior were reported in patients treated with Otezla or treated with placebo
Weight Decrease: Monitor body weight regularly; evaluate unexplained or clinically significant weight loss, and consider discontinuation of Otezla
Plaque Psoriasis: Body weight loss of 5-10% occurred in 12% (96/784) of patients with moderate to severe plaque psoriasis treated with Otezla and in 5% (19/382) of patients treated with
placebo. Body weight loss of ≥10% occurred in 2% (16/784) of patients treated with Otezla compared to 1% (3/382) of patients treated with placebo
Psoriatic Arthritis: Body weight loss of 5-10% was reported in 10% (49/497) of patients taking Otezla and in 3.3% (16/495) of patients taking placebo
Behçet’s Disease: Body weight loss of >5% was reported in 4.9% (5/103) of patients taking Otezla and in 3.9% (4/102) of patients taking placebo
Drug Interactions: Apremilast exposure was decreased when Otezla was co-administered with rifampin, a strong CYP450 enzyme inducer; loss of Otezla efficacy may occur. Concomitant use of Otezla with CYP450 enzyme inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended
Plaque Psoriasis: The most common adverse reactions (≥5%) are diarrhea, nausea, upper respiratory tract infection, and headache, including tension headache. Overall, the safety profile of Otezla
in patients with mild to moderate plaque psoriasis was consistent with the safety profile previously established in adult patients with moderate to severe plaque psoriasis
Psoriatic Arthritis: The most common adverse reactions (≥5%) are diarrhea, nausea, and headache
Behçet’s Disease: The most common adverse reactions (≥10%) are diarrhea, nausea, headache, and upper respiratory tract infection
Use in Specific Populations
Otezla has not been studied in pregnant women. Advise pregnant women of the potential risk of fetal loss
Please click here for the full Prescribing Information.
Otezla® (apremilast) is indicated for the treatment of adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy.
Otezla is indicated for the treatment of adult patients with active psoriatic arthritis.
Otezla is indicated for the treatment of adult patients with oral ulcers associated with Behçet’s Disease.
References: 1. Otezla [package insert]. Thousand Oaks, CA: Amgen Inc.