Otezla is the first and only oral therapy approved across all severities of adult plaque psoriasis SEE THE DATA
OTEZLA IS THE FIRST AND ONLY ORAL THERAPY
APPROVED ACROSS ALL SEVERITIES OF ADULT PLAQUE PSORIASIS
TREAT MULTIPLE MANIFESTATIONS OF PLAQUE PSORIASIS WITH OTEZLA 1,3,4,6


*Efficacy of Otezla in nail psoriasis was studied in the ADVANCE clinical trial for patients with mild to moderate plaque psoriasis. Analysis is exploratory and has not been adjusted for multiple comparisons. No conclusions of statistical or clinical significance can be drawn.
MILD TO MODERATE PLAQUE PSORIASIS:
- In ADVANCE, 22% of patients taking Otezla (n=297) achieved an sPGA score of 0 (clear) or 1 (almost clear) and a ≥2-point reduction from baseline vs 4% with placebo (n=298) at week 16 (P<0.0001; primary endpoint; ITT population) 1,3
MODERATE TO SEVERE PLAQUE PSORIASIS:
- In ESTEEM 1, 33% of patients taking Otezla (n=562) achieved PASI-75 response vs 5% with placebo (n=282) at week 16 (P<0.0001; primary endpoint) 1,4
- In ESTEEM 2, 29% of patients taking Otezla (n=274) achieved PASI-75 response vs 6% with placebo (n=137) at week 16 (P<0.001; primary endpoint) 5
- In LIBERATE, 40% of patients taking Otezla (n=83) achieved PASI-75 response vs 12% with placebo (n=84) at week 16 (P<0.0001; primary endpoint) 2
- In STYLE, 43% of patients taking Otezla (n=201) achieved a significant improvement in ScPGA response vs 14% with placebo (n=102) at week 16 (P<0.0001; primary endpoint; ITT population; MI analysis) 7