copaydosingefficacyresourcesafety

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Dosing

Otezla® (apremilast) is administered orally1

GETTING STARTED ON OTEZLA

After an initial 5-day titration period, the maintenance dose of Otezla is 30 mg twice daily1

5-day titration schedule

Day 1
Day 2
Day 3
Day 4
Day 5
Day 6 and thereafter
AMAMPMAMPMAMPMAMPMAMPM
10
mg
10
mg
10
mg
10
mg
20
mg
20
mg
20
mg
20
mg
30
mg
30
mg
30
mg
 
AM
PM
Day 110 mg-
Day 210 mg10 mg
Day 310 mg20 mg
Day 420 mg20 mg
Day 520 mg30 mg
Day 6 and thereafter30 mg30 mg
  • This titration is intended to reduce the gastrointestinal symptoms associated with initiation of therapy
  • Otezla can be administered without regard to meals
  • Patients should not crush, split, or chew the tablet

The dose of Otezla should be reduced to 30 mg once daily in patients with severe renal impairment1*

  • For initial dosage titration, it is recommended that Otezla be titrated using only the AM schedule shown above and the PM doses be skipped
  • From day 6 on, the dose of Otezla is 30 mg once daily
*

Creatinine clearance (CrCl) <30 mL/min estimated by the Cockcroft–Gault equation.

Otzela 30 mg Starter Pack

Package of the Otezla® 30mg Starter Pack, including dosage information

Reference: 1. Otezla [package insert]. Summit, NJ: Celgene Corporation.

Indications & Important Safety Information

Please click here for Full Prescribing Information.

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8 out of 10commercially insured lives in the US have preferred access with no biologic step required for Otezla® (apremilast)1

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Reference: 1. Data on file, Celgene Corporation.
01/18 USII-APR180063