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Dosing

Otezla® (apremilast) is administered orally1

GETTING STARTED ON OTEZLA

After an initial 5-day titration period, the maintenance dose of Otezla is 30 mg twice daily1

5-day titration schedule

Day 1
Day 2
Day 3
Day 4
Day 5
Day 6 and thereafter
5-day titration schedule
AMAMPMAMPMAMPMAMPMAMPM
10
mg
10
mg
10
mg
10
mg
20
mg
20
mg
20
mg
20
mg
30
mg
30
mg
30
mg
 
AM
PM
Day 110 mg-
Day 210 mg10 mg
Day 310 mg20 mg
Day 420 mg20 mg
Day 520 mg30 mg
Day 6 and thereafter30 mg30 mg
  • This titration is intended to reduce the gastrointestinal symptoms associated with initiation of therapy
  • Otezla can be administered without regard to meals
  • Patients should not crush, split, or chew the tablet

The dose of Otezla should be reduced to 30 mg once daily in patients with severe renal impairment1*

  • For initial dosage titration, it is recommended that Otezla be titrated using only the AM schedule shown above and the PM doses be skipped
  • From day 6 on, the dose of Otezla is 30 mg once daily
*

Creatinine clearance (CrCl) <30 mL/min estimated by the Cockcroft–Gault equation.

Otezla Starter Pack

Package of the Otezla® 30mg Starter Pack, including dosage information

Reference: 1. Otezla [package insert]. Summit, NJ: Celgene Corporation.

Indications & Important Safety Information

Please click here for Full Prescribing Information.

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