Otezla® (apremilast) is administered orally1
  • Dosing
  • How to Start

After an initial 5-day titration period, the maintenance dose of Otezla is 30 mg twice daily1

5-day titration schedule

Day 1
Day 2Day 3Day 4Day 5
Day 6 and
10 mg10 mg10 mg10 mg20 mg20 mg20 mg20 mg30 mg30 mg30 mg
Day 110 mg
Day 210 mg10 mg
Day 310 mg20 mg
Day 420 mg20 mg
Day 520 mg30 mg
Day 6 and
30 mg30 mg
  • This titration is intended to reduce the gastrointestinal symptoms associated with initiation of therapy
  • Otezla can be administered without regard to meals
  • Patients should not crush, split, or chew the tablet

The dose of Otezla should be reduced to 30 mg once daily in patients with severe renal impairment1*

  • For initial dosage titration, it is recommended that Otezla be titrated using only the AM schedule shown above and the PM doses be skipped
  • From day 6 on, the dose of Otezla is 30 mg once daily

Creatinine clearance (CrCl) <30 mL/min estimated by the Cockcroft–Gault equation.

Otzela 30 mg Starter Pack

Otezla® (apremilast) starter pack

Starting with in-office sample:

Otezla 30 mg Starter Pack

  • 2 weeks of medication, including 5 days of titration doses

Otezla 30 mg Bridge Pack

  • Commercial patients denied or waiting for coverage can receive a free supply of Otezla for up to 3 years*

Starting with the specialty pharmacy:

Otezla 30 mg 28-Day Pack

  • Includes 5 days of titration doses and additional maintenance doses if Starter Pack is not provided in office

Otezla 30 mg 30-Day Supply

  • Maintenance doses for patients who have received benefit verification

Ensure your patient has received a sample Starter Pack prior to enrolling. To receive a free bridge supply of Otezla, patients must have an on-label diagnosis. Patients in Massachusetts are not eligible to receive bridge.

Patients that do not receive a sample Starter Pack will only receive Otezla after insurance approval.

Reference: 1. Otezla [package insert]. Summit, NJ: Celgene Corporation.

Indications & Important Safety Information

Please click here for Full Prescribing Information.

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Reference: 1. Data on file, Celgene Corporation.
01/18 USII-APR180004