Treating with Otezla

Otezla® (apremilast) is administered orally.1
  • Dosing
  • How to start
  • After an initial 5-day titration period, the maintenance dose of Otezla® (apremilast) is 30 mg twice daily1

5-day titration schedule

Day 1
Day 2Day 3Day 4Day 5
Day 6 and
10 mg10 mg10 mg10 mg20 mg20 mg20 mg20 mg30 mg30 mg30 mg
Day 110 mg
Day 210 mg10 mg
Day 310 mg20 mg
Day 420 mg20 mg
Day 520 mg30 mg
Day 6 and
30 mg30 mg
  • This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy
  • Otezla can be administered without regard to meals
  • Patients should not crush, split, or chew the tablet

Dosage adjustment in patients with severe renal impairment1*

  • Otezla dosage should be reduced to 30 mg once daily in patients with severe renal impairment
  • For initial dosage titration, it is recommended that Otezla be titrated using only the AM schedule shown above and the PM doses be skipped. From day 6 on, the dose of Otezla is 30 mg once daily

Creatinine clearance (CrCl) <30 mL/min estimated by the Cockcroft–Gault equation.

Otzela 30-mg Starter Pack

Otezla® (apremilast) starter pack

Reference: 1. Otezla [package insert]. Summit, NJ: Celgene Corporation.

Starting with in-office sample:

Otezla® (apremilast) 30-mg Starter Pack

  • 2 weeks of medication, including 5 days of titration doses

Otezla 30-mg Bridge Pack

  • For patients who need a temporary supply of Otezla until they receive their 30-day supply

Starting with the specialty pharmacy:

Otezla 30-mg 28-Day Pack

  • Includes 5 days of titration doses and additional maintenance doses if Starter Pack is not provided in office

Otezla 30-mg 30-Day Supply

  • Maintenance doses for patients who have received benefit verification

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Indications & Important Safety Information

Please click here for Full Prescribing Information.

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