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Mechanism of Action

  • Mechanism of Action Video
  • Mechanism of Action Diagram

Learn more about the intracellular mechanism of action of Otezla® (apremilast) in the video below.

Otezla is a non-biologic oral PDE4 inhibitor with a distinct mechanism of action1

The role of phosphodiesterase 4 (PDE4) and cAMP in controlling inflammation2-4

learn about the role of PDE4 and cAMP in controlling inflammation

Inflammatory cell

Visual representation based on preclinical evidence

  • Cyclic adenosine monophosphate (cAMP) is a second messenger for a variety of inflammatory mediators2
  • PDE4 is a cAMP-specific PDE that has been shown to degrade cAMP to AMP in inflammatory cells1,2,5
  • The balance between cAMP and AMP within a cell may modulate the expression of pro-inflammatory and anti-inflammatory mediators4

Otezla inhibits PDE4 intracellularly1

learn about the mechanism of action of Otezla® (apremilast)

Inflammatory cell

Visual representation based on preclinical evidence

  • By elevating cAMP levels, Otezla® (apremilast) is thought to indirectly modulate production of inflammatory mediators3,4
  • The specific mechanism(s) by which apremilast exerts its therapeutic action in patients with psoriatic arthritis is not well defined1

References: 1. Otezla [package insert]. Summit, NJ: Celgene Corporation. 2. Moore AR, Willoughby DA. Clin Exp Immunol. 1995;101(3):387-389. 3. Schafer PH, Parton A, Gandhi AK, et al. Br J Pharm. 2010;159(4):842-855. 4. Schafer P. Biochem Pharmacol. 2012;83(12):1583-1590. 5. Soto FJ, Hanania NA. Curr Opin Pulm Med. 2005;11(2):129-134.

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Indications & Important Safety Information

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